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Resensation^®

What is AVANCE^® (acellular nerve allograft-arwx)?

AVANCE is a sterile nerve graft prepared from donated human tissue. AVANCE is implanted in patients with cut nerves to help restore sensory function.

Important Safety Information

AVANCE has risks related to surgery and the use of donated human tissue that you should understand before treatment.

Surgical and Procedure-Related Risks

As with any nerve repair surgery, complications can occur. Risks related to the surgical procedure and use of AVANCE may include pain, increased sensitivity at the implant site, swelling, bleeding, and infection. Other risks may include scarring (including thick or raised scars), delayed wound healing, scar tissue, and formation of a painful nerve growth. Some patients may experience loss, decrease, or change in sensation or movement in the area being treated. A serious problem involving wound healing has also been reported.

Risk of Infectious Disease Transmission

Because AVANCE is made from donated human tissue, it can pass on infectious diseases. Donors are carefully screened and tested for viruses and other infectious agents. However, these measures do not completely eliminate the risk of disease transmission. All infections thought to be transmitted by AVANCE should be reported to Axogen Corporation at 1-888-296-4361.

What to Watch for After Surgery

After your procedure, your doctor will monitor your healing and nerve recovery. Contact your healthcare provider right away if you notice any of the following:

• Redness, swelling, warmth, or increasing pain at the surgical site
• Drainage or signs of infection
• New or worsening numbness, tingling, or pain
• Changes in movement or weakness
• Any other symptoms that concern you

Always follow your healthcare provider’s instructions during recovery and rehabilitation.